Below are details of the amendments that were published on 10 November 2008 (see update index for all updates)
| Section | Details of update |
| CISR11060 | Reference in the instruction to the leaflet IR56 replaced with Factsheet ES/FS2 |
| CISR11070 | Reference in the instruction to the leaflet IR56 replaced with Factsheet ES/FS2 |
| CISR13010 | Reference in the instruction to the leaflet IR56 replaced with Factsheets ES/FS1 and ES/FS2 |
| CISR19050 | Instruction clarified to confirm that a Scheme Specific Agent cannot be authorised to act for CIS using form 64-8. |
| CISR43070 | Text amended to introduce a de-minimus limit in respect of small payments of £99.99 or less either paid late or still outstanding. |
| CISR46010 | Text amended to include reference to SI2008/1282 |
| CISR46040 | Text amplified regarding the Compliance Test and beneficial shareholders for a ‘close’ company. |
| CISR46060 | Text amended to introduce a de-minimus limit in respect of small payments of £99.99 or less either paid late or still outstanding. |
| CISR46080 | Text amended to introduce a de-minimus limit in respect of small payments of £99.99 or less either paid late or still outstanding. |
| CISR51010 | Text amended to remove the text on Unmatched verification and regarding the verification of deceased subcontractors |
| CISR51120 | New instruction created regarding Unmatched verifications |
| CISR51130 | This instruction has moved from CISR51120 |
| CISR51140 | This instruction has moved from CISR51130 |
| CISR67010 | Text amended to confirm that from 27th October 2008 CIS will now automatically set a 6 month period of Inactivity where requested, even if there are returns outstanding in respect of previous months. |
| CISR67620 | Text amended to confirm that from 27th October 2008 CIS will now automatically set a 6 month period of Inactivity where requested, even if there are returns outstanding in respect of previous months. |